If you are a woman and your father had hemophilia, you are always a carrier. The IHTC comprehensive care team has genetic counselors, psychologists, social workers, and a number of other professionals who will guide and support you in every stage of taking care of yourself as a carrier, as well as planning for a family through evaluating reproductive options, genetic testing, emotional support, and education.
It is important for you to partner with the IHTC on getting education related to the amazing medical advances in the field of hemophilia, and also the responsibilities of being not only the daughter of a parent with hemophilia, the sister of someone with hemophilia, but also the parent, or future parent, of a child with hemophilia.
We invite you to stay connected to the multiple educational sessions at IHTC for carriers, and educational resources that are made available. Women with low factor levels may be at risk for heavy menstrual periods, bruising, and nosebleeds. When injury causes a blood vessel to bleed, vascular constriction limits the flow of blood to the injured area. The vessel wall injury, via a series of reactions, triggers the attachment and activation of platelets which aggregates at the site of injury.
Platelets adhere to collagen which becomes exposed in the endothelial cell lining of blood vessels at the site of injury creating the platelet plug. Initial platelet adhesion is to von Willebrand factor, a major component in the blood coagulation process.
Coagulation factor VIII circulates in the blood stream in an inactive form when bound to von Willebrand factor. When injury to a blood vessel occurs, factor VIII becomes activated and separates from von Willebrand factor and interacts with factor IX, another coagulation factor. This interaction sets off a chain of additional chemical reactions that form a blood clot.
Activation of a sequence of blood clotting factors generates thrombin which converts fibrinogen to fibrin. Fibrin mesh is then produced around the hemostatic plug in turn strengthening the clot. It occurs due to decrease in or malfunctioning von Willebrand factor activity which ultimately affects the hemostasis process and slows the formation of blood clots resulting in prolonged bleeding episodes.
Hemophilia is a bleeding disorder where the blood is unable to clot properly. Platelets also need clotting factors. These are proteins that form a "web" around the platelets, helping them to stay in place.
There are several different clotting factors in the blood. They're numbered using Roman numerals. A child with haemophilia B does not have enough clotting factor IX 9 in their blood. Page last reviewed: 17 April Next review due: 17 April Haemophilia is caused by an inherited change to a gene. It mainly affects males. The occurrence of hemophilia A factor VIII deficiency is around 1 in 4, live male births worldwide. The occurrence of hemophilia B factor IX deficiency is 1 in 20, live male births worldwide.
Hemophilia A accounts for most cases. Female carriers of the gene may show some mild signs of factor VIII deficiency, such as bruising easily or taking longer than usual to stop bleeding when cut.
But not all female carriers have these symptoms. One-third of all cases are thought to be new mutations in the family not inherited from the mother.
Treatment for hemophilia B includes replacement of factor IX. Search Encyclopedia.
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