When was gentamicin created

Jackson is a professor of medicine in the Department of Medicine and an attending physician on the staff of the Research and Educational Hospitals of the University of Illinois. A laboratory and clinical evaluation was made of gentamicin sulfate which is a new antibiotic produced by a species of the genus Micromonospora. It has a broad spectrum that includes both Pseudomonas and Proteus organisms; staphylococci also are susceptible in vitro. Intramuscular injection produced antibacterial concentrations in the serum and urine.

The drug is excreted almost entirely in active form by the kidney by glomerular filtration with little or no reabsorption. Uncomplicated urinary tract infections were successfully treated; cases with complicating conditions often relapsed.

Gram-negative bacteremia responded infrequently to the doses used, but treatment was sometimes life saving. Labyrinthine intoxication was the only serious side effect observed and was always associated with pre-existing renal failure or a large dose. Coronavirus Resource Center. Our website uses cookies to enhance your experience. He lived until the age of 94, passing away peacefully on 19 August Wife Margaret had died three years earlier. The world of new drug discovery shall miss this great leader as it struggles to solve the problems brought on by the antibiotic crisis of today, that is, the lack of new antibiotics to battle resistant pathogens and newly emerged disease agents.

You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Demain, A. Remembering Marvin Weinstein — J Antibiot 65, — Download citation. Published : 27 July Issue Date : July Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Antibiotics Scientific community. View author publications. Rights and permissions Reprints and Permissions. About this article Cite this article Demain, A. Antimicrob Agents Chemother. Circadian variations in serum levels and the renal toxicity of aminoglycosides in patients.

Clin Pharmacol Ther. Aminoglycoside administration as a single daily dose. An improvement to current practice or a repeat of previous errors? Aminoglycosides: single or multiple daily dosing? A meta-analysis on efficacy and safety. Eur J Clin Pharmacol. Once-daily aminoglycoside dosing in immunocompetent adults: a meta-analysis.

Ann Intern Med. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin Infect Dis. A meta-analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides. Single daily dosing of aminoglycosides in immunocompromised adults: a systematic review.

Mega-analysis of meta-analysis: an examination of meta-analysis with an emphasis on once-daily aminoglycoside comparative trials. Effectiveness and safety of once-daily aminoglycosides: a meta-analysis. Am J Health Syst Pharm. The evolution of aminoglycoside therapy: a single daily dose. Am Fam Physician. Antimicrobial practice. Development of guidelines for gentamicin dosing. J Antimicrob Chemother.

Drug facts and comparisons. Louis, Mo. Bansal RC. Pharmacoeconomic impact of once-daily aminoglycoside administration. Richard W. Sloan, M. Hospital and clinical associate professor in family and community medicine at the Milton S. This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference.

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Purchase Access: See My Options close. Best Value! To see the full article, log in or purchase access. More in Pubmed Citation Related Articles. Email Alerts Don't miss a single issue. Sign up for the free AFP email table of contents. Navigate this Article. Serious, life-threatening gram-negative infection. Complicated skin, bone or soft tissue infection. Complicated urinary tract infection. Peritonitis and other severe intra-abdominal infections.

Severe pelvic inflammatory disease. Mycobacterium infection. Ocular infections topical. Otitis externa topical. Ciprofloxacin Cipro. Imipenem-cilastatin Primaxin. Piperacillin-tazobactam Zosyn. Ticarcillin-clavulanate Timentin. Potentially alterable factors.

Radiographic contrast exposure. Effective circulating volume depletion. Use of other nephrotoxic medications. Concomitant use of amphotericin Fungizone IV. Use of cisplatin Platinol. Unalterable factors. Pre-existing renal disease. Ali, et al. Netilmicin Netromycin. Streptococcal and enterococcal endocarditis. Streptomycin, 7. Staphylococcal endocarditis.

Amikacin Amikin : IV. Netilmicin Netromycin : IV.